TSHZ3
Sign in to saveAlso known as TSH3, ZNF537, teashirt zinc finger homeobox 3
Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene. In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.
Gene data
TSHZ3- Name
- teashirt zinc finger homeobox 3
- Type
- protein-coding
- Aliases
- TSH3, ZNF537
This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016].
via MyGene.info
Gene · Ensembl
teashirt zinc finger homeobox 3
- Symbol
- TSHZ3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:31,149,979-31,349,814
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TSHZ3 PDB 2dmi.png
Show 5 more facts
- HomoloGene ID
- 10835
- exact match
- identifiers.org/ncbigene/57616
- genomic end
- 31349436
- genomic start
- 31149979
- cytogenetic location
- 19q12
Sources (3)
via Wikidata · CC0
~2 min read
Article
3 sectionsContents
- References
- Further reading
- External links
Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene. In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.
Tshz3-knockout mice do not develop the respiratory rhythm generator (RRG) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG neurons are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz3 is being studied for its relationship to infant breathing defects in humans.