Vinculin
Sign in to savethumb|Vinculin is a globular protein approximately 115 x 85 x 65 angstroms in linear dimension. In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.
Key facts
- Protein family.Symbol
- VBS
- Protein family.Name
- VBS
- Protein family.image
- PDB 1rkc EBI.jpg
- Protein family.caption
- human vinculin head (1-258) in complex with talin's vinculin binding site 3 (residues 1944-1969)
- Protein family.Pfam
- PF08913
- Protein family.InterPro
- IPR015009
via Wikipedia infobox
Article
9 sectionsContents
- Structure
- Mechanism and function
- Activation
- Binding site
- Splice variants
- Interactions
- References
- Further reading
- External links
thumb|Vinculin is a globular protein approximately 115 x 85 x 65 angstroms in linear dimension. In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.
Discovered independently by Benny Geiger and Keith Burridge, its sequence is 20%–30% similar to α-catenin, which serves a similar function.