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yangonin
Sign in to saveAlso known as 4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one
Yangonin is one of the six major kavalactones found in the kava plant. It acts as a selective agonist at the CB1 cannabinoid receptor, inhibits monoamine oxidase (particularly MAO-B), and modulates GABAA receptor activity. Yangonin significantly reduces nociception and inflammatory hyperalgesia via spinal CB1 receptors in rats, highlighting its potential as a promising treatment for pain. It is the strongest COX-II inhibitor among the six major kavalactones. Yangonin also exhibits neuroprotective, antifungal, and antimicrobial properties, though it has shown toxicity to human hepatocytes in vi
Wikidata facts
- Subclass of
- kavalactone
- Mass
- 258.089209
Show 5 more facts
- canonical SMILES
- COC1=CC=C(C=C1)C=CC2=CC(=CC(=O)O2)OC
- chemical formula
- C₁₅H₁₄O₄
- isomeric SMILES
- COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=O)O2)OC
- found in taxon
- Piper majusculum
- Commons category
- Yangonin
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
4 sectionsContents
- Pharmacology
- Toxicity
- Biosynthesis
- References
Yangonin is one of the six major kavalactones found in the kava plant. It acts as a selective agonist at the CB1 cannabinoid receptor, inhibits monoamine oxidase (particularly MAO-B), and modulates GABAA receptor activity. Yangonin significantly reduces nociception and inflammatory hyperalgesia via spinal CB1 receptors in rats, highlighting its potential as a promising treatment for pain. It is the strongest COX-II inhibitor among the six major kavalactones. Yangonin also exhibits neuroprotective, antifungal, and antimicrobial properties, though it has shown toxicity to human hepatocytes in vitro.
==Pharmacology==
Excerpted from Wikipedia’s “yangonin” article, available under the CC BY-SA 4.0 licence.