YAP1
Sign in to saveAlso known as COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator
YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases. YAP1 is a potent oncogene, which is amplified in various human cancers.
Gene data
YAP1- Name
- Yes1 associated transcriptional regulator
- Type
- protein-coding
- Position
- 102,109,968–102,233,534 (+)
- Aliases
- COB1, YAP, YAP-1, YAP2, YAP65, YKI
- Ensembl
- ENSG00000137693
- RefSeq RNA
- NM_001130145.3, NM_001195044.2, NM_001195045.2, NM_001282097.2, NM_001282098.2
- RefSeq protein
- NP_001123617.1, NP_001181973.1, NP_001181974.1, NP_001269026.1, NP_001269027.1
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
Yes1 associated transcriptional regulator
- Symbol
- YAP1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:102,109,968-102,233,534
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein YAP1 PDB 1jmq.png
Show 7 more facts
- HomoloGene ID
- 4452
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10413
- genomic end
- 102233424
- genomic start
- 102110447
- chromosome
- human chromosome 11
- cytogenetic location
- 11q22.1
via Wikidata · CC0
Article · 日本語
YAP1（yes-associated protein 1）は、転写因子として機能するタンパク質であり、細胞増殖に関与する遺伝子の転写を活性化しアポトーシスに関与する遺伝子を抑制する。YAP、YAP65とも呼ばれる。YAP1は、器官のサイズの制御や腫瘍の抑制を可能にするHippoシグナル伝達経路によって阻害される。YAP1はやSrcといったチロシンキナーゼのSH3ドメインに結合することから初めて同定された。YAP1をコードするYAP1遺伝子は強力ながん遺伝子であり、ヒトのさまざまながんで増幅されている。
Abstract from DBpedia / Wikipedia · CC BY-SA