Structure via PubChem · Public domain (PubChem)
2-chlorodiazepam
Sign in to saveAlso known as 7-chloro-5-(2-chlorophenyl)-1-methyl-1H-benzo[e][1,4]diazepin-2(3H)-one, Diclazepam
Diclazepam (Ro5-3448), also known as chlorodiazepam and '''2'-chloro-diazepam''', is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans.
Chemical data
- Formula
- C16H12Cl2N2O
- Molecular weight
- 319.2 g/mol
- IUPAC name
- 7-chloro-5-(2-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
13 papers- Overdose from designer benzodiazepine Diclazepam.QJM : monthly journal of the Association of Physicians · 2020
- Designer benzodiazepines versus prescription benzodiazepines: can structural relation predict the next step?Critical reviews in toxicology · 2021
- Discriminative stimulus and reinforcing effects of diclazepam in rodents.Pharmacology, biochemistry, and behavior · 2024
- Organ distribution of diclazepam, pyrazolam and 3-fluorophenmetrazine.Forensic science international · 2019
- Highly Efficient Dual-Color Luminophores for Sensitive and Selective Detection of Diclazepam Based on MOF/COF Bi-Mesoporous Composites.ACS sensors · 2023
via PubMed
Wikidata facts
- Mass
- 318.033
Show 4 more facts
- chemical formula
- C₁₆H₁₂Cl₂N₂O
- canonical SMILES
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3Cl
- Commons category
- Diclazepam
- found in taxon
- potato
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Metabolism
- Legal status
- United Kingdom
- United States
- See also
- References
Diclazepam (Ro5-3448), also known as chlorodiazepam and '''2'-chloro-diazepam', is a benzodiazepine and functional analog of diazepam. It was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. It is not currently approved for use as a medication, but rather sold as an unscheduled substance. Efficacy and safety have not been tested in humans.
In animal models, its effects are similar to diazepam, possessing long-acting anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.
Excerpted from Wikipedia’s “2-chlorodiazepam” article, available under the CC BY-SA 4.0 licence.