Also known as 24,25-Dihydroxyvitamin D₃, 24-Hydroxycalcidiol
24,25-Dihydroxycholecalciferol, also known as 24,25-dihydroxyvitamin D3, refers to a mixture of epimers hydroxycalcidiol and hydroxycalcidiol (abbreviated as and ) closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3. Like vitamin D3 itself and calcifediol (25-hydroxyvitamin D3), it is inactive as a hormone both in vitro and in vivo. It was first identified in 1972 in the laboratory of Hector DeLuca and Michael F. Holick.
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24,25-Dihydroxycholecalciferol, also known as 24,25-dihydroxyvitamin D3, refers to a mixture of epimers hydroxycalcidiol and hydroxycalcidiol (abbreviated as and ) closely related to 1,25-dihydroxyvitamin D3, the active form of vitamin D3. Like vitamin D3 itself and calcifediol (25-hydroxyvitamin D3), it is inactive as a hormone both in vitro and in vivo. It was first identified in 1972 in the laboratory of Hector DeLuca and Michael F. Holick.
==Formation and significance== 24(R),25-(OH)2D3 is formed from 25-hydroxyvitamin D3 by the action of CYP24A1 (25-hydroxyvitamin D3-24-hydroxylase). CYP24A1 appears to be "a multicatalytic enzyme catalyzing most, if not all, of the reactions in the C-24/C-23 pathway of 25-OH-D3 metabolism." 24(S),25-(OH)2D3 is derived from reduction of 25-OH-24-oxo-D3, a metabolite of 24(R),25-(OH)2D3.
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