Also known as 4(1H)-Quinolone, γ-Quinolone, 4-Quinolone, 1,4-Dihydro-4-quinolinone, 1H-4-Oxoquinoline, 1H-Quinolin-4-one
4-Quinolone is an organic compound derived from quinoline. It and 2-quinolone are the two most important parent (meaning simplified) quinolones. 4-Quinolone exists in equilibrium with a minor tautomer, 4-hydroxyquinoline (CAS#611-36-9). Aside from pedagogical interest, 4-quinolone is of little intrinsic value but its derivatives, the 4-quinolone antibiotics, represent a large class of important drugs. thumb|left|The tautomeric equilibrium relating 4-quinolone (right) and 4-hydroxyquinoline (left)
4-Quinolone is an organic compound derived from quinoline. It and 2-quinolone are the two most important parent (meaning simplified) quinolones. 4-Quinolone exists in equilibrium with a minor tautomer, 4-hydroxyquinoline (CAS#611-36-9). Aside from pedagogical interest, 4-quinolone is of little intrinsic value but its derivatives, the 4-quinolone antibiotics, represent a large class of important drugs. thumb|left|The tautomeric equilibrium relating 4-quinolone (right) and 4-hydroxyquinoline (left)
==Synthesis== The chemical synthesis of quinolones often involves ring-closing reactions. Such reactions often install a hydroxyl group (an –OH functional group) on the carbon across from the ring nitrogen (i.e., the C-4 positions). An example of such a synthesis is the Camps cyclization, which, depending on starting materials and reaction conditions, can give both 2-hydroxyquinolines (B) and 4-hydroxyquinolines (A) as shown. The hydroxyquinolines tautomerize to the quinolones.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).