ACP1

Also known as HAAP, LMW-PTP, acid phosphatase 1, soluble, LMWPTP, acid phosphatase 1

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.

Gene data

ACP1

Name: acid phosphatase 1
Type: protein-coding
Aliases: HAAP, LMW-PTP, LMWPTP

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008].

via MyGene.info

Gene · Ensembl

acid phosphatase 1

Symbol: ACP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:264,140-280,057
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein ACP1 PDB 1bvh.png

Show 5 more facts

HomoloGene ID: 38274
exact match: identifiers.org/ncbigene/52
genomic end: 278283
genomic start: 264140
cytogenetic location: 2p25.3

Sources (4)

via Wikidata · CC0

~2 min read

Article

5 sections

Contents

Clinical significance
Interactions
References
External links
Further reading

Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.