Structure via PubChem · Public domain (PubChem)
acrivastine
Sign in to saveAlso known as BW 825C, (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid, BW A825C, (2E)-3-{6-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridin-2-yl}acrylic acid
Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors.
Chemical data
- Formula
- C22H24N2O2
- Molecular weight
- 348.4 g/mol
- IUPAC name
- (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]-2-pyridinyl]prop-2-enoic acid
- SMILES
- CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC(=N3)/C=C/C(=O)O
- InChIKey
- PWACSDKDOHSSQD-IUTFFREVSA-N
- XLogP
- 1.6
- Polar surface area
- 53.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1994
- Admin. routes
- oral
- Indications
- allergic disease
via ChEMBL · EBI
Research
112 papers- Acrivastine.2006
- Acrivastine.2012
- Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders.Drugs · 1991
- Second-generation antihistamines: a comparative review.Drugs · 1999
- Acrivastine in allergic rhinitis: a review of clinical experience.The Journal of international medical research · 1989
via PubMed
Wikidata facts
- Mass
- 348.183778
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₂H₂₄N₂O₂
- canonical SMILES
- CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC(=N3)C=CC(=O)O
- isomeric SMILES
- CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC(=N3)/C=C/C(=O)O
- World Health Organisation international non-proprietary name
- acrivastine
- medical condition treated
- urticaria
- Commons category
- Acrivastine
- defined daily dose
- 24
via Wikidata · CC0
~3 min read
Encyclopedic overview
2 sectionsContents
- Comparisons with other popular antihistamines
- References
{{Drugbox | Verifiedfields = changed | verifiedrevid = 477241254 | IUPAC_name = (E)-3-{6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridin-2-yl}prop-2-enoic acid | image = Acrivastine.svg | image_class = skin-invert-image
| tradename = | Drugs.com = | pregnancy_AU = | legal_AU = | legal_CA = | legal_UK = GSL | legal_US = Rx-only | routes_of_administration = By mouth
Excerpted from Wikipedia’s “acrivastine” article, available under the CC BY-SA 4.0 licence.