Actinin alpha 3
Sign in to saveAlso known as alpha-actinin skeletal muscle, Alpha-actinin skeletal muscle isoform 3, actinin, alpha 3, F-actin cross-linking protein, alpha-actinin-3, ACTN3
Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the ACTN3 gene (named sprinter gene, speed gene or athlete gene) located on chromosome 11. All people have two copies (alleles) of this gene.
Protein · UniProt
Alpha-actinin-3
- Gene
- ACTN3
- Organism
- Homo sapiens (Human)
- Length
- 901 aa
- Molecular mass
- 103,241 Da
- Evidence
- 1: Evidence at protein level
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein
Swiss-Prot (reviewed) · via UniProt
~3 min read
Encyclopedic overview
8 sectionsContents
- Fast versus slow twitch muscle fibers
- Alleles
- Athletes
- Interactions
- See also
- References
- Further reading
- External links
Alpha-actinin-3, also known as alpha-actinin skeletal muscle isoform 3 or F-actin cross-linking protein, is a protein that in humans is encoded by the ACTN3 gene (named sprinter gene, speed gene or athlete gene) located on chromosome 11. All people have two copies (alleles) of this gene.
Alpha-actinin is an actin-binding protein with multiple roles in different cell types. This gene expression is limited to skeletal muscle. It is localized to the Z-disc and analogous dense bodies, where it helps to anchor the myofibrillar actin filaments.
Excerpted from Wikipedia’s “Actinin alpha 3” article, available under the CC BY-SA 4.0 licence.