ACTN2

Name

actinin alpha 2

Type

protein-coding

Position

236,664,141–236,764,631 (+)

Aliases

CMD1AA, CMH23, CMYO8, CMYP8, MPD6, MYOCOZ

Ensembl

ENSG00000077522

RefSeq RNA

NM_001103.4, NM_001278343.2, NR_184402.1

RefSeq protein

NP_001094.1, NP_001265272.1

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].

via MyGene.info

Gene · Ensembl

actinin alpha 2

Symbol

ACTN2

Biotype

Protein coding

Organism

Homo sapiens

Location

1:236,664,141-236,764,631

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein ACTN2 PDB 1h8b.png

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