titin
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Key facts
- Protein family.Pfam
- PF06582
- Protein family.Name
- Titin repeat
- Protein family.Symbol
- Titin_Ig-rpts
- Protein family.InterPro
- IPR010939
via Wikipedia infobox
Article
13 sectionsContents
- Discovery
- Genetics
- Isoforms
- Structure
- Evolution
- Function
- Clinical relevance
- Interactions
- Linguistic significance
- See also
- References
- Further reading
- External links
thumb|Cardiac#Microanatomy|Cardiac sarcomere structure, featuring titin thumb|Reconstruction of the thin (green) and thick filament from mammalian cardiac tissue. Myosin is in blue, MyBP-C is in yellow, and titin is in two shades of red (dark red for titin-alpha and light red for titin-beta).
Titin (; also called connectin) is a protein that in humans is encoded by the TTN gene. The protein, which is over 1 μm in length, functions as a molecular spring that is responsible for the passive elasticity of muscle. It comprises 244 individually folded protein domains connected by unstructured peptide sequences. These domains unfold when the protein is stretched and refold when the tension is removed.