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titin
ProteinQ74314· pop 36· linked from 727 articles

titin

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Also known as rhabdomyosarcoma antigen MU-RMS-40.14, connectin, Ttn, TTN

<!-- DO NOT ADD THE FULL CHEMICAL NAME OF TITIN INTO THIS ARTICLE.

OverviewAI-generated

Titin is a protein encoded by the TTN gene in Homo sapiens. It has a length of 34350 and a mass of 3816030. The protein is associated with keywords including 3D-structure, Alternative splicing, ATP-binding, Calcium, and Calmodulin-binding. Its existence is supported by evidence at the protein level, and it is classified under the EC enzyme number 2.7.11.1.

The chemical formula for titin is listed as C₁₆₉₇₂₃H₂₇₀₄₆₄N₄₅₆₈₈O₅₂₂₄₃S₉₁1123fr. In scientific literature, there are 4057 PubMed records and 4 ClinicalTrials.gov entries associated with the query "titin". The subject is referenced by 727 other encyclopedia articles.

Synthesized by Vinony from 17 facts across 5 sources: Wikidata, PubMed, ClinicalTrials.gov, UniProt, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Protein family.Pfam
PF06582
Protein family.Name
Titin repeat
Protein family.Symbol
Titin_Ig-rpts
Protein family.InterPro
IPR010939

via Wikipedia infobox

Protein · UniProt

Titin

Gene
TTN
Organism
Homo sapiens (Human)
Length
34,350 aa
Molecular mass
3,816,030 Da
Evidence
1: Evidence at protein level

Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase

3D-structureAlternative splicingATP-bindingCalciumCalmodulin-bindingCardiomyopathyCoiled coilCytoplasm
View on UniProt →

Swiss-Prot (reviewed) · via UniProt

Research

4,057 papers

via PubMed

Clinical Trials

4 registered

via ClinicalTrials.gov

Wikidata facts

Instance of
protein
Subclass of
protein
Part of
Immunoglobulin-like domain superfamily
Show 4 more facts
chemical formula
C₁₆₉₇₂₃H₂₇₀₄₆₄N₄₅₆₈₈O₅₂₂₄₃S₉₁1123fr
EC enzyme number
2.7.11.1
found in taxon
Homo sapiens
Commons category
Titin
Sources (5)

via Wikidata · CC0

~13 min read

Encyclopedic overview

13 sections
Contents
  • Discovery
  • Genetics
  • Isoforms
  • Structure
  • Evolution
  • Function
  • Clinical relevance
  • Interactions
  • Linguistic significance
  • See also
  • References
  • Further reading
  • External links

thumb|Cardiac#Microanatomy|Cardiac sarcomere structure, featuring titin thumb|Reconstruction of the thin (green) and thick filament from mammalian cardiac tissue. Myosin is in blue, MyBP-C is in yellow, and titin is in two shades of red (dark red for titin-alpha and light red for titin-beta).

Titin (; also called connectin) is a protein that in humans is encoded by the TTN gene. The protein, which is over 1 μm in length, functions as a molecular spring that is responsible for the passive elasticity of muscle. It comprises 244 individually folded protein domains connected by unstructured peptide sequences. These domains unfold when the protein is stretched and refold when the tension is removed.

Excerpted from Wikipedia’s “titin” article, available under the CC BY-SA 4.0 licence.

Gallery (8)

Available in 35 languages

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via Wikidata sitelinks · CC0