titin
Sign in to saveAlso known as rhabdomyosarcoma antigen MU-RMS-40.14, connectin, Ttn, TTN
<!-- DO NOT ADD THE FULL CHEMICAL NAME OF TITIN INTO THIS ARTICLE.
Key facts
- Protein family.Pfam
- PF06582
- Protein family.Name
- Titin repeat
- Protein family.Symbol
- Titin_Ig-rpts
- Protein family.InterPro
- IPR010939
via Wikipedia infobox
Research
4,057 papers- Titin (TTN): from molecule to modifications, mechanics, and medical significance.Cardiovascular research · 2022
- Discovery of Titin and Its Role in Heart Function and Disease.Circulation research · 2025
- Titin N2A Domain and Its Interactions at the Sarcomere.International journal of molecular sciences · 2021
- The giant titin: how to evaluate its role in cardiomyopathies.Journal of muscle research and cell motility · 2019
- Titin fragment in urine: A noninvasive biomarker of muscle degradation.Advances in clinical chemistry · 2019
via PubMed
Clinical Trials
4 registered- ENROLLING_BY_INVITATIONThe Validity of Urinary Titin and Skeletal Muscle Index as Predictor of Muscle Weakness in Critically Ill Patients. A Prospective Cohort StudyZagazig University · NCT06487728
- PHASE2TERMINATEDExploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other CausalitiesBristol-Myers Squibb · NCT04572893
- RECRUITINGCongenital Muscle Disease Study of Patient and Family Reported Medical InformationCure CMD · NCT01403402
- NARECRUITINGUrinary Titin Biomarker in DMDChildren's Hospital of Philadelphia · NCT07332013
Wikidata facts
Show 3 more facts
- chemical formula
- C₁₆₉₇₂₃H₂₇₀₄₆₄N₄₅₆₈₈O₅₂₂₄₃S₉₁1123fr
- EC enzyme number
- 2.7.11.1
- Commons category
- Titin
via Wikidata · CC0
~13 min read
Article
13 sectionsContents
- Discovery
- Genetics
- Isoforms
- Structure
- Evolution
- Function
- Clinical relevance
- Interactions
- Linguistic significance
- See also
- References
- Further reading
- External links
thumb|Cardiac#Microanatomy|Cardiac sarcomere structure, featuring titin thumb|Reconstruction of the thin (green) and thick filament from mammalian cardiac tissue. Myosin is in blue, MyBP-C is in yellow, and titin is in two shades of red (dark red for titin-alpha and light red for titin-beta).
Titin (; also called connectin) is a protein that in humans is encoded by the TTN gene. The protein, which is over 1 μm in length, functions as a molecular spring that is responsible for the passive elasticity of muscle. It comprises 244 individually folded protein domains connected by unstructured peptide sequences. These domains unfold when the protein is stretched and refold when the tension is removed.