Structure via PubChem · Public domain (PubChem)
alizapride
Sign in to saveAlso known as Plitican, Alizaprida, Alizapridum
Alizapride (Litican, Plitican, Superan, Vergentan) is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides.
In the Vinony graph
Within Vinony's link graph, alizapride is referenced by 530 other articles, and connects out to L-scopolamine, kidney and International Standard Book Number.
Vinony files it under Allylamines, Antiemetics and Benzotriazoles.
Its subject is documented across 12 Wikipedia language editions.
Chemical data
- Formula
- C16H21N5O2
- Molecular weight
- 315.37 g/mol
- IUPAC name
- 6-methoxy-N-[(1-prop-2-enylpyrrolidin-2-yl)methyl]-2H-benzotriazole-5-carboxamide
- SMILES
- COC1=CC2=NNN=C2C=C1C(=O)NCC3CCCN3CC=C
- InChIKey
- KSEYRUGYKHXGFW-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 83.1 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- gastrointestinal disease
via ChEMBL · EBI
Research
115 papers- Therapeutic Use of Cannabis and Cannabinoids: A Review.JAMA · 2026
- Alizapride in prevention of postoperative nausea and vomiting.The Netherlands journal of surgery · 1988
- Alizapride and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic gynaecological surgery: A double-blind, randomised, placebo-controlled noninferiority study.European journal of anaesthesiology · 2016
- [Pharmacodynamics of alizapride (author's transl)].La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris · 1982
- Activity of a new antiemetic agent: alizapride. A randomized double-blind crossover controlled trial.Cancer chemotherapy and pharmacology · 1988
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 315.169525
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₆H₂₁N₅O₂
- MCN code
- 2933.99.44
- canonical SMILES
- COC1=CC2=NNN=C2C=C1C(=O)NCC3CCCN3CC=C
- Commons category
- Alizapride
- subject has role
- antiemetic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Mechanism
- Synthesis
- References
Alizapride (Litican, Plitican, Superan, Vergentan) is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. It is structurally related to metoclopramide and other benzamides.
== Mechanism == Alizapride blocks D2 dopamine receptors in the vomiting center.
Excerpted from Wikipedia’s “alizapride” article, available under the CC BY-SA 4.0 licence.