آمیلوراید

Also known as amiloride HCl, Midamor®, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide, 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Amiloride, Amiloridum, Amipramidine, Amilorida

Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. Amiloride is classified as a potassium-sparing diuretic. Amiloride is often used together with another diuretic, such as a thiazide or loop diuretic. It is taken by mouth. Onset of action is about two hours and it lasts for about a day.

Chemical data

Formula: C6H8ClN7O
Molecular weight: 229.63 g/mol
IUPAC name: 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
InChIKey: XSDQTOBWRPYKKA-UHFFFAOYSA-N
XLogP: -0.7
Polar surface area: 159 Å²
H-bond donors: 4
H-bond acceptors: 5
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1981
Admin. routes: oral
Indications: cardiovascular disease, hypertension, coronary artery disease, attention deficit hyperactivity disorder

via ChEMBL · EBI

Research

12,588 papers

Amiloride: A review.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2020
Amiloride and calciuria.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
Amiloride and its analogs as tools in the study of ion transport.The Journal of membrane biology · 1988
Amiloride-induced hyponatremia.Acta medica Scandinavica · 1980
Amiloride and vertebrate gustatory responses to NaCl.Neuroscience and biobehavioral reviews · 1998

via PubMed