Structure via PubChem · Public domain (PubChem)
Amiloride
Sign in to saveAlso known as amiloride HCl, Midamor®, N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide, 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Amiloridum, Amipramidine, Amilorida
farmaco
Chemical data
- Formula
- C6H8ClN7O
- Molecular weight
- 229.63 g/mol
- IUPAC name
- 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
- SMILES
- C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
- InChIKey
- XSDQTOBWRPYKKA-UHFFFAOYSA-N
- XLogP
- -0.7
- Polar surface area
- 159 Ų
- H-bond donors
- 4
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1981
- Admin. routes
- oral
- Indications
- cardiovascular disease, hypertension, coronary artery disease, attention deficit hyperactivity disorder
via ChEMBL · EBI
Research
12,588 papers- Amiloride: A review.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2020
- Amiloride and calciuria.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
- Amiloride and its analogs as tools in the study of ion transport.The Journal of membrane biology · 1988
- Amiloride-induced hyponatremia.Acta medica Scandinavica · 1980
- Amiloride and vertebrate gustatory responses to NaCl.Neuroscience and biobehavioral reviews · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 229.048
- Has use
- medication
Show 10 more facts
- chemical formula
- C₆H₈ClN₇O
- medical condition treated
- nephrogenic diabetes insipidus
- subject has role
- essential medicine
- isomeric SMILES
- C1(=C(N=C(C(=N1)Cl)N)N)/C(=N/C(=N)N)/O
- canonical SMILES
- C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
- Commons category
- Amiloride
- defined daily dose
- 10
- stylized name
- aMILoride
- significant drug interaction
- valsartan
- World Health Organisation international non-proprietary name
- amiloride
via Wikidata · CC0
Article · Italiano
L'amiloride fa parte dei farmaci diuretici risparmiatori di potassio. Viene somministrata per compensare gli effetti di altri diuretici che aumentano l'escrezione di K+. Utilizzato principalmente per curare ipertensione. L’amiloride agisce bloccando i canali del sodio, collocati sulla membrana luminale delle cellule tubulo contorto distale e dei dotti collettori. Questo provoca una iperpolarizzazione della membrana luminale, con conseguente riduzione della velocità di escrezione di alcuni cationi: K+, H+, Ca2+ e Mg2+. In Italia è in commercio nella specialità Moduretic.
Abstract from DBpedia / Wikipedia · CC BY-SA