Ascofuranone is an antibiotic produced by various ascomycete fungi including Acremonium sclerotigenum that inhibits the Trypanosoma brucei alternative oxidase and is a lead compound in efforts to produce other drugs targeting this enzyme for the treatment of sleeping sickness. The compound is effective both in vitro cell culture and in infections in mice.
{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 457819837 | Name = Ascofuranone | ImageFile = Ascofuranone structure.png | ImageSize = 240 | ImageAlt = Structural formula of ascofuranone | ImageFile1 = Ascofuranone 3D ball.png | ImageSize1 = 250 | ImageAlt1 = Space-filling model of the ascofuranone molecule | PIN = 3-Chloro-5-{(2E,6E)-7-[(2S)-5,5-dimethyl-4-oxooxolan-2-yl]-3-methylocta-2,6-dien-1-yl}-4,6-dihydroxy-2-methylbenzaldehyde | OtherNames = Ascofuranon |Section1= |Section2= }} Ascofuranone is an antibiotic produced by various ascomycete fungi including Acremonium sclerotigenum that inhibits the Trypanosoma brucei alternative oxidase and is a lead compound in efforts to produce other drugs targeting this enzyme for the treatment of sleeping sickness. The compound is effective both in vitro cell culture and in infections in mice.
Ascofuranone has also been reported to have anti-tumor activity, and modulate the immune system. __TOC__ == Biosynthesis == The proposed biosynthesis of ascofuranone was reported by Kita et al., as well as by Abe et al. The prenylation of orsellinic acid, followed by terminal cyclization through epoxidation is how ascofuranone can be synthesized. Compound (1), ilicicolinic acid B, was found to be produced from polyketide synthase (PKS) StBA and that AscCABD are responsible for the biosynthesis of ilicicolin A (3). Ilicicolin B (2) was found to be produced by expressing AscC (polyketide synthase) which is then followed by expression of AscA (prenyltransferase). AscD (flavin-dependent halogenase, flavin binding enzyme) is able to catalyze the chlorination of ilicicolinic acid B (2) to yield ilicicolin A (3).
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).