atipamezole
Sign in to saveAtipamezole, sold under the brand name Antisedan among others, is a synthetic α2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α2-adrenergic receptors and displacing them. It is mainly used in veterinary medicine, and while it is only licensed for dogs and for intramuscular use, it has been used intravenously, as well as in cats and other animals (intravenous use in cats and dogs is not recommended due to the potential for cardiovascular collaps
Research
1,118 papers- Atipamezole.Compendium (Yardley, PA) · 2008
- Comparison of sedation with dexmedetomidine/atipamezole administered subcutaneously at GV20 acupuncture point with usual routes of administration in dogs presented for orthopaedic radiographs.The Journal of small animal practice · 2023
- Effects of atipamezole on selected physiologic parameters in cynomolgus macaques (Macaca fascicularis).Journal of medical primatology · 2024
- Enhancing glymphatic fluid transport by pan-adrenergic inhibition suppresses epileptogenesis in male mice.Nature communications · 2024
- Atipamezole Reverses Cardiovascular Changes Induced by High-Dose Medetomidine in Cats Undergoing Sedation for Semen Collection.Animals : an open access journal from MDPI · 2023
via PubMed
Wikidata facts
- Mass
- 212.131
Show 3 more facts
- chemical formula
- C₁₄H₁₆N₂
- canonical SMILES
- CCC1(CC2=CC=CC=C2C1)C3=CN=CN3
- Commons category
- Atipamezole
via Wikidata · CC0
~9 min read
Encyclopedic overview
14 sectionsContents
- Veterinary use
- Available forms
- Specific populations
- Contraindications
- Side effects
- Overdose
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Research
- Notes
- References
- Further reading
- External links
Atipamezole, sold under the brand name Antisedan among others, is a synthetic α2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α2-adrenergic receptors and displacing them. It is mainly used in veterinary medicine, and while it is only licensed for dogs and for intramuscular use, it has been used intravenously, as well as in cats and other animals (intravenous use in cats and dogs is not recommended due to the potential for cardiovascular collapse. This occurs due to profound hypotension caused by reversal of the alpha 1 effects while the reflex bradycardia is still in effect.). There is a low rate of side effects, largely due to atipamezole's high specificity for the α2-adrenergic receptor. Atipamezole has a very quick onset, usually waking an animal up within 5 to 10 minutes.
It was originally released in 1996. It is available in as a generic medication.
Excerpted from Wikipedia’s “atipamezole” article, available under the CC BY-SA 4.0 licence.