Structure via PubChem · Public domain (PubChem)
benazepril
Sign in to saveAlso known as CIB824, CGS-14824A, Lotensin®, 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-, Benazeprilum
Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.
Key facts
- Drug.verifiedrevid
- 459529583
- Drug.image
- Benazepril structure.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Benazepril-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Lotensin, others
- Drug.MedlinePlus
- a692011
- Drug.DailyMedID
- Benazepril
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C09
- Drug.ATC_suffix
- AA07
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.protein_bound
- 96.7%
- Drug.metabolism
- Liver glucuronidation
- Drug.elimination_half life
- 10-11 hours
- Drug.excretion
- Kidney and bile duct
- Drug.CAS_number
- 86541-75-5
via Wikipedia infobox
Chemical data
- Formula
- C24H28N2O5
- Molecular weight
- 424.5 g/mol
- IUPAC name
- 2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]azaniumyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetate
- SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)[NH2+][C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)[O-]
- InChIKey
- XPCFTKFZXHTYIP-PMACEKPBSA-N
- XLogP
- 1.9
- Polar surface area
- 103 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
927 papers- Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.The New England journal of medicine · 2008
- Benazepril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in hypertension and congestive heart failure.Drugs · 1991
- Comparison of benazepril and other antihypertensive agents alone and in combination with the diuretic hydrochlorothiazide.Clinical cardiology · 1991
- Renoprotective effects of benazepril: current perspective.Expert review of cardiovascular therapy · 2011
- Antihypertensive and organ-protective effects of benazepril.Expert review of cardiovascular therapy · 2010
via PubMed
Wikidata facts
- Mass
- 424.199822
Show 6 more facts
- chemical formula
- C₂₄H₂₈N₂O₅
- canonical SMILES
- CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O
- isomeric SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O
- World Health Organisation international non-proprietary name
- benazepril
- defined daily dose
- 7.5
- Commons category
- Benazepril
Sources (6)
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Medical uses
- Side effects
- Contraindications
- Dosage forms
- Veterinary uses
- References
Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.
Common side effects include feeling tired, dizziness, cough, and light-headedness with standing. Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema. Use in pregnancy may harm the baby, while use when breastfeeding may be safe. It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.