BIRC2
Sign in to saveAlso known as API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, baculoviral IAP repeat containing 2
gène de l'espèce Homo sapiens
Gene data
BIRC2- Name
- baculoviral IAP repeat containing 2
- Type
- protein-coding
- Position
- 102,347,208–102,378,680 (+)
- Aliases
- API1, HIAP2, Hiap-2, IAP-2, MIHB, RNF48, c-IAP1, cIAP1
- Ensembl
- ENSG00000110330
- RefSeq RNA
- NM_001166.5, NM_001256163.1, NM_001256166.2, XM_054368611.1, XM_054368612.1
- RefSeq protein
- NP_001157.1, NP_001243092.1, NP_001243095.1, XP_054224586.1, XP_054224587.1
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology
Biological process
protein polyubiquitinationresponse to hypoxiainflammatory responsecell surface receptor signaling pathwaycanonical NF-kappaB signal transductioncanonical NF-kappaB signal transductionextrinsic apoptotic signaling pathway via death domain receptorsintrinsic apoptotic signaling pathway in response to DNA damage
Molecular function
Pathways
NF-kappa B signaling pathway - Homo sapiens (human)Ubiquitin mediated proteolysis - Homo sapiens (human)Apoptosis - Homo sapiens (human)Apoptosis - multiple species - Homo sapiens (human)Necroptosis - Homo sapiens (human)Hippo signaling pathway - Homo sapiens (human)Focal adhesion - Homo sapiens (human)NOD-like receptor signaling pathway - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Salmonella infection - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
baculoviral IAP repeat containing 2
- Symbol
- BIRC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:102,347,208-102,378,680
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI