BMPR1A

Also known as 10q23del, ACVRLK3, ALK3, CD292, SKR5, bone morphogenetic protein receptor type 1A

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292).

Gene data

BMPR1A

Name: bone morphogenetic protein receptor type 1A
Type: protein-coding
Position: 86,755,763–86,932,825 (+)
Aliases: 10q23del, ACVRLK3, ALK-3, ALK3, BMPR-1A, CD292, SKR5
Ensembl: ENSG00000107779
RefSeq RNA: NM_001406559.1, NM_001406560.1, NM_001406561.1, NM_001406562.1, NM_001406563.1
RefSeq protein: NP_001393488.1, NP_001393489.1, NP_001393490.1, NP_001393491.1, NP_001393492.1

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008].