بریمونیدین

Also known as Alphagan®, Mirvaso®, UK14,304, UK14304, Bromoxidine, 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline, Brimonidine, Brimonidinum

Brimonidine is an α2 agonist medication used to treat open-angle glaucoma, ocular hypertension, and rosacea. In rosacea it improves the redness. It is used as eye drops or applied to the skin. It is also available in the fixed-dose combination medication brimonidine/timolol along with timolol maleate.

Key facts

Drug.legal_US: Rx-only
Drug.Watchedfields: changed
Drug.verifiedrevid: 459982442
Drug.image: Brimonidine.svg
Drug.image_class: skin-invert-image
Drug.width: 195
Drug.tradename: Alphagan, Mirvaso, Lumify, others
Drug.MedlinePlus: a601232
Drug.DailyMedID: Brimonidine
Drug.pregnancy_AU: B3
Drug.routes_of_administration: Topical
Drug.ATC_prefix: D11
Drug.ATC_suffix: AX21
Drug.ATC_supplemental: , ,
Drug.legal_AU: S4
Drug.legal_AU_comment: /Schedule 2
Drug.legal_US_comment: / OTC
Drug.metabolism: Primarily liver

via Wikipedia infobox

Chemical data

Formula: C11H10BrN5
Molecular weight: 292.13 g/mol
IUPAC name: 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
SMILES: C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
InChIKey: XYLJNLCSTIOKRM-UHFFFAOYSA-N
XLogP: 0.6
Polar surface area: 62.2 Å²
H-bond donors: 2
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1996
Admin. routes: topical
Indications: diabetic retinopathy, open-angle glaucoma, rosacea, dry eye syndrome

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 291.012
Has use: medication

Show 7 more facts

chemical formula: C₁₁H₁₀BrN₅
World Health Organisation international non-proprietary name: brimonidine
medical condition treated: glaucoma
canonical SMILES: C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
subject has role: alpha-adrenergic agonist
contraindicated in case of: lactation
Commons category: Brimonidine

Sources (3)

via Wikidata · CC0

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via Wikidata sitelinks · CC0