budipine

Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.

Chemical data

Formula: C21H27N
Molecular weight: 293.4 g/mol
IUPAC name: 1-tert-butyl-4,4-diphenylpiperidine
SMILES: CC(C)(C)N1CCC(CC1)(C2=CC=CC=C2)C3=CC=CC=C3
InChIKey: QIHLUZAFSSMXHQ-UHFFFAOYSA-N
XLogP: 5.2
Polar surface area: 3.2 Å²
H-bond donors: 0
H-bond acceptors: 1
Formal charge: 0

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Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: Parkinson disease

via ChEMBL · EBI

Research

73 papers

Budipine in Parkinson's tremor.Journal of the neurological sciences · 2006
Clinical efficacy of budipine in Parkinson's disease.Journal of neural transmission. Supplementum · 1999
Multiple mechanisms of action: the pharmacological profile of budipine.Journal of neural transmission. Supplementum · 1999
Budipine provides additional benefit in patients with Parkinson disease receiving a stable optimum dopaminergic drug regimen.Archives of neurology · 2002
Non-dopaminergic therapy in Parkinson's disease.Journal of neurology · 2000

via PubMed

Wikidata facts

Subclass of: heterocyclic compound
Has part: carbon
Mass: 293.214

Show 5 more facts

Commons category: Budipine
chemical formula: C₂₁H₂₇N
canonical SMILES: CC(C)(C)N1CCC(CC1)(C2=CC=CC=C2)C3=CC=CC=C3
subject has role: antiparkinson
medical condition treated: Parkinson's disease

Sources (4)

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Encyclopedic overview

3 sections

Contents

Synthesis
See also
References

Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.

While its exact mechanism of action is not well characterized, it is believed to be an NMDA receptor antagonist, but also promoting the synthesis of dopamine.

Excerpted from Wikipedia’s “budipine” article, available under the CC BY-SA 4.0 licence.

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