bufotenine
Sign in to saveBufotenin, also known as dimethylserotonin or as '5-hydroxy-N,N-dimethyltryptamine (5-HO-DMT'), is a serotonergic psychedelic of the tryptamine family. It is a derivative of the psychedelic dimethyltryptamine (DMT) and of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). The compound is an alkaloid found in some species of mushrooms, plants, and toads. It is also found naturally in the human body in small amounts. Bufotenin, for instance derived from the trees Anadenanthera colubrina and Anadenanthera peregrina, has a long history of entheogenic use as a snuff in South America.
Key facts
- Drug.Watchedfields
- verified
- Drug.verifiedrevid
- 443669819
- Drug.image
- Bufotenin2DACS.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225px
- Drug.image2
- Bufotenin-3d-sticks.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 225px
- Drug.legal_AU
- S9
- Drug.legal_CA
- Unscheduled
- Drug.legal_DE
- NpSG
- Drug.legal_UK
- Class A
- Drug.legal_US
- Schedule I
- Drug.legal_status
- Illegal in Sweden
- Drug.routes_of_administration
- Oral, intranasal/insufflation, inhalation, sublingual, rectal, intravenous
- Drug.class
- Serotonergic psychedelic; Hallucinogen; Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist
- Drug.bioavailability
- Weakly active (with or without )
- Drug.metabolism
- Deamination via and conjugation (glucuronidation, sulfation)
via Wikipedia infobox
Article
39 sectionsContents
- Use and effects
- Fabing & Hawkins (1955)
- Isbell (1956)
- Turner & Merlis (1959)
- Hofmann (1963)
- McLeod and Sitaram (1985)
- Shulgin (1997)
- Ott (2001)
- Morris (2020s)
- Side effects
- Overdose
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Chemistry
- Properties
- Synthesis
- Analogues and derivatives
- Natural occurrence
- Toads
- ''Anadenanthera'' seeds
- Other sources
- Occurrence in humans
- Association with psychiatric conditions
- History
- Society and culture
- Names
- Recreational use
- Legal status
- Australia
- Canada
- Sweden
- United Kingdom
- United States
- Research
- See also
- References
- External links
Bufotenin, also known as dimethylserotonin or as '5-hydroxy-N,N-dimethyltryptamine (5-HO-DMT'), is a serotonergic psychedelic of the tryptamine family. It is a derivative of the psychedelic dimethyltryptamine (DMT) and of the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT). The compound is an alkaloid found in some species of mushrooms, plants, and toads. It is also found naturally in the human body in small amounts. Bufotenin, for instance derived from the trees Anadenanthera colubrina and Anadenanthera peregrina, has a long history of entheogenic use as a snuff in South America.
The name bufotenin originates from the toad genus Bufo, which includes several species of psychoactive toads, most notably Incilius alvarius (formerly Bufo alvarius), that secrete bufotoxins from their parotoid glands. However, Bufo and related species like Incilius alvarius contain only trace amounts of bufotenin, with their major active component instead being 5-MeO-DMT. In addition to DMT and serotonin, bufotenin is similar in chemical structure to other psychedelics such as 5-MeO-DMT and psilocin (4-HO-DMT). These compounds also occur in some of the same fungus, plant, and animal species as bufotenin.