EntityQ4046265· pop 19· linked from 2,788 articles

(RS)-methylone

Methylone, also known as '3,4-methylenedioxy-N-methylcathinone (MDMC'), is an entactogen and stimulant drug of the amphetamine, cathinone, and MDxx families related to 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy"). It is the β-keto or cathinone analogue of MDMA. The drug is usually taken orally, but can also be administered by other routes.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 457117430
Drug.image: Methylone structure.svg
Drug.image_class: skin-invert-image
Drug.width: 235px
Drug.image2: MDMC-3d-sticks.png
Drug.image_class2: bg-transparent
Drug.width2: 250px
Drug.routes_of_administration: Common: oral, insufflationUncommon: IV or IM injection, rectal
Drug.class: Serotonin–norepinephrine–dopamine releasing agent; Entactogen
Drug.ATC_prefix: None
Drug.legal_AU: Unscheduled
Drug.legal_BR: F2
Drug.legal_CA: Schedule I
Drug.legal_UK: Class B
Drug.legal_US: Schedule I
Drug.legal_DE: Anlage II

via Wikipedia infobox

Article

23 sections

Contents

Use and effects
Interactions
Pharmacology
Pharmacodynamics
Pharmacokinetics
Chemistry
Synthesis
History
Society and culture
Names and etymology
Commercial distribution
Legal status
Netherlands
New Zealand
United Kingdom
Sweden
Canada
United States
Research
Post-traumatic stress disorder
See also
References
External links

It acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA). The drug has much less activity at the vesicular monoamine transporter 2 (VMAT2) than MDMA and may have less serotonergic neurotoxicity. In contrast to certain other entactogens like MDMA, methylone does not appear to be a significant agonist of the serotonin 5-HT2 receptors. Methylone is similar in its effects to MDMA, producing entactogenic effects and euphoria, but has a reputation of being gentler than MDMA and only lasts about half as long. Side effects of methylone include tachycardia, hangover, and insomnia. It may have reduced negative after-effects compared to MDMA. Methylone's onset is about 0.5hours and its duration is about 2 to 3hours.