CCN1

Also known as GIG1, IGFBP10, cysteine rich angiogenic inducer 61, cellular communication network factor 1, CYR61

CCN family member 1 (CCN1) or Cysteine-rich angiogenic inducer 61 (CYR61), is a matricellular protein that in humans is encoded by the CYR61 gene.

Gene data

CCN1

Name: cellular communication network factor 1
Type: protein-coding
Position: 85,580,756–85,584,589 (+)
Aliases: CYR61, GIG1, IBP-10, IGFBP-10, IGFBP10
Ensembl: ENSG00000142871
RefSeq RNA: NM_001554.5
RefSeq protein: NP_001545.2

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011].

Gene Ontology

Biological process

cell adhesion signal transduction signal transduction integrin-mediated signaling pathway positive regulation of cell migration positive regulation of cell migration positive regulation of bone mineralization positive regulation of BMP signaling pathway

Molecular function

integrin binding integrin binding extracellular matrix structural constituent protein binding heparin binding extracellular matrix binding

Cellular component

extracellular region extracellular region endoplasmic reticulum lumen extracellular matrix extracellular matrix

Pathways

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)Metabolism of proteins Post-translational protein modification Post-translational protein phosphorylation Oncostatin M Signaling Pathway VEGFA-VEGFR2 Signaling Pathway Hypertrophy Model

via MyGene.info

Wikidata facts

Image: CYR61 protein.png

Show 5 more facts

HomoloGene ID: 1194
exact match: identifiers.org/ncbigene/3491
genomic end: 85584589
genomic start: 86046444
cytogenetic location: 1p22.3

Sources (6)

via Wikidata · CC0

~11 min read

Article

14 sections

Contents

CCN protein family
Gene structure and regulation
Protein structure and function
Structural domains
Integrin binding
Cell signaling and function
Embryonic development
Clinical relevance
Wound healing and fibrosis
Inflammation
Arthritis
Vascular diseases
Cancer
References

CCN family member 1 (CCN1) or Cysteine-rich angiogenic inducer 61 (CYR61), is a matricellular protein that in humans is encoded by the CYR61 gene.

CCN1 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CCN1 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CCN1 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CCN1 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.