CDH12
Sign in to saveAlso known as CDHB, cadherin 12
Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.
Gene data
CDH12- Name
- cadherin 12
- Type
- protein-coding
- Position
- 21,750,673–22,853,344 (−)
- Aliases
- CDHB
- Ensembl
- ENSG00000154162
- RefSeq RNA
- NM_001317227.2, NM_001317228.1, NM_001364104.2, NM_001364105.2, NM_001364106.2
- RefSeq protein
- NP_001304156.1, NP_001304157.1, NP_001351033.1, NP_001351034.1, NP_001351035.1
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Wikidata facts
Show 6 more facts
- HomoloGene ID
- 37873
- exact match
- identifiers.org/ncbigene/1010
- genomic end
- 22853731
- genomic start
- 21750782
- cytogenetic location
- 5p14.3
- Commons category
- Cadherin-12
Sources (3)
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- Further reading
- External links
Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.