CDH12

Also known as CDHB, cadherin 12

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.

In the Vinony graph

Within Vinony's link graph, CDH12 is referenced by 107 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 5.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CDH12

Name: cadherin 12
Type: protein-coding
Position: 21,750,673–22,853,344 (−)
Aliases: CDHB
Ensembl: ENSG00000154162
RefSeq RNA: NM_001317227.2, NM_001317228.1, NM_001364104.2, NM_001364105.2, NM_001364106.2
RefSeq protein: NP_001304156.1, NP_001304157.1, NP_001351033.1, NP_001351034.1, NP_001351035.1

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015].

Gene Ontology

Biological process

cell morphogenesis cell-cell junction assembly cell adhesion homophilic cell-cell adhesion calcium-dependent cell-cell adhesion cell migration adherens junction organization cell-cell adhesion mediated by cadherin

Molecular function

calcium ion binding beta-catenin binding cadherin binding

Cellular component

plasma membrane plasma membrane adherens junction membrane catenin complex

Pathways

Cell-Cell communication Adherens junctions interactions Cell-cell junction organization Cell junction organization Pathways Regulating Hippo Signaling Hippo-Merlin Signaling Dysregulation

via MyGene.info

Gene · Ensembl

cadherin 12

Symbol: CDH12
Biotype: Protein coding
Organism: Homo sapiens
Location: 5:21,750,673-22,853,344
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 37873
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1010
genomic end: 22853731
genomic start: 21750782
chromosome: human chromosome 5
cytogenetic location: 5p14.3
expressed in: entorhinal cortex
Commons category: Cadherin-12

Sources (3)

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Encyclopedic overview

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Contents

References
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External links

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Excerpted from Wikipedia’s “CDH12” article, available under the CC BY-SA 4.0 licence.