N-カドヘリン
Sign in to saveAlso known as CD325, CDHN, CDw325, NCAD, cadherin 2, ACOGS, ARVD14
Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2 gene. CDH2 has also been designated as CD325 (cluster of differentiation 325). Cadherin-2 is a transmembrane protein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including hu
Gene data
CDH2- Name
- cadherin 2
- Type
- protein-coding
- Position
- 27,932,879–28,178,024 (−)
- Aliases
- ACOGS, ADHD8, ARVD14, CD325, CDHN, CDw325, NCAD
- Ensembl
- ENSG00000170558
- RefSeq RNA
- NM_001308176.2, NM_001792.5, XM_011525788.1, XM_017025514.3, XM_054318138.1
- RefSeq protein
- NP_001295105.1, NP_001783.2, XP_011524090.1, XP_016881003.1, XP_054174113.1
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cadherin 2
- Symbol
- CDH2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 18:27,932,879-28,178,024
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CDH2 PDB 1ncg.png
Show 10 more facts
- HomoloGene ID
- 20424
- genetic association
- obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1000
- genomic end
- 28177946
- genomic start
- 27932879
- chromosome
- human chromosome 18
- cytogenetic location
- 18q12.1
- expressed in
- middle temporal gyrus
- Commons category
- N-cadherin (neural)
via Wikidata · CC0
Article · 日本語
N-カドヘリン（neural cadherin, NCAD）またはカドヘリン2（cadherin-2, CDH2）は、ヒトではCDH2遺伝子にコードされるタンパク質である。CD325（cluster of differentiation 325）とも表記される。N-カドヘリンは複数の組織で発現している膜貫通タンパク質であり、細胞間接着を媒介する機能を果たす。心筋においては、N-カドヘリンは介在板に位置するアドヘレンスジャンクションの重要な構成要素である。介在板は、隣接する心筋細胞との機械的・電気的に共役する機能を果たす。N-カドヘリンタンパク質の発現や完全性の変化は、拡張型心筋症などさまざまな疾患で観察される。CDH2遺伝子の変異は症候群性神経発達障害を引き起こすことも特定されている。
Abstract from DBpedia / Wikipedia · CC BY-SA