CENPT
Sign in to saveAlso known as C16orf56, CENP-T, centromere protein T, SSMGA
Centromere protein T is a protein that in humans is encoded by the CENPT gene.
Gene data
CENPT- Name
- centromere protein T
- Type
- protein-coding
- Position
- 67,828,157–67,847,811 (−)
- Aliases
- C16orf56, CENP-T, SSMGA
- Ensembl
- ENSG00000102901
- RefSeq RNA
- NM_025082.4, XM_017023717.2, XM_024450455.2, XM_024450456.2, XM_047434686.1
- RefSeq protein
- NP_079358.3, XP_016879206.1, XP_024306223.1, XP_024306224.1, XP_047290642.1
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
centromere protein T
- Symbol
- CENPT
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 16:67,828,157-67,847,811
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
5 sectionsContents
- Clinical significance
- See also
- References
- External links
- Further reading
Centromere protein T is a protein that in humans is encoded by the CENPT gene.
== Clinical significance == Mutations in CENPT cause an autosomal recessive syndrome of microcephaly, short stature, skeletal abnormalities, underdeveloped genitalia and pubertal delay.
Excerpted from Wikipedia’s “CENPT” article, available under the CC BY-SA 4.0 licence.