CENPM
Sign in to saveAlso known as C22orf18, CENP-M, PANE1, bK250D10.2, centromere protein M
Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.
Gene data
CENPM- Name
- centromere protein M
- Type
- protein-coding
- Aliases
- C22orf18, CENP-M, PANE1
The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 11438
- exact match
- identifiers.org/ncbigene/79019
- genomic end
- 41947152
- genomic start
- 41938737
- cytogenetic location
- 22q13.2
Sources (4)
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Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.
An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells. Centromere protein M is involved in centromere assembly and immune response.