English
cetraxate
Sign in to saveAlso known as 3-[4-[[trans-4-(aminomethyl)cyclohexyl]-oxomethoxy]phenyl]propanoic acid
Cetraxate (INN) is an oral gastrointestinal medication which has a cytoprotective effect.
Research
88 papers- Biocatalytic deprotection of a cetraxate ester by Microbacterium sp. strain 7-1W cells.Bioscience, biotechnology, and biochemistry · 2003
- [Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 1985
- Cytoprotective action of cetraxate against HCl.ethanol-induced gastric lesion in rats.Japanese journal of pharmacology · 1988
- Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma.The Journal of pharmacy and pharmacology · 2004
- Comparison of cetraxate-based and pantoprazole-based triple therapies in the treatment of Helicobacter pylori infection.Journal of the Chinese Medical Association : JCMA · 2004
via PubMed
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Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Cetraxate (INN) is an oral gastrointestinal medication which has a cytoprotective effect.
==Synthesis== Cetraxate is a prodrug of tranexamic acid. The latter is a hemostatic agent because it inhibits the activation of plasminogen to plasmin. The result is to prevent excess loss of blood in gastrointestinal ulcers. The synthesis begins with the esterification of 3-(p-hydroxyphenyl)propionic acid (2) by trans-4-cyanocyclohexanecarbonyl chloride (1). The product (3) is reduced to cetraxate (4) by catalytic hydrogenation with hydrogen and Raney nickel. thumb|center|700px|class=skin-invert-image|Cetraxate synthesis
Excerpted from Wikipedia’s “cetraxate” article, available under the CC BY-SA 4.0 licence.