Structure via PubChem · Public domain (PubChem)
cyclopenthiazide
Sign in to saveAlso known as cyclomethiazide, SU-8341, NAX341
Cyclopenthiazide (trade name Navidrex) is a thiazide diuretic used in the treatment of heart failure and hypertension.
Chemical data
- Formula
- C13H18ClN3O4S2
- Molecular weight
- 379.9 g/mol
- IUPAC name
- 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
- SMILES
- C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl
- InChIKey
- BKYKPTRYDKTTJY-UHFFFAOYSA-N
- XLogP
- 1.3
- Polar surface area
- 135 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
175 papers- Drug-induced pancreatitis: an update.Journal of clinical gastroenterology · 2005
- [Cyclopenthiazide therapy].[Sogo rinsho] Clinic all-round · 1963
- [ON CYCLOPENTHIAZIDE (AWD-DRESDEN) THERAPY].Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete · 1964
- The case for low dose diuretics in hypertension: comparison of low and conventional doses of cyclopenthiazide.BMJ (Clinical research ed.) · 1988
- Xipamide and cyclopenthiazide in essential hypertension--comparative effects on blood pressure and plasma potassium.British journal of clinical pharmacology · 1982
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 379.042726
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₃H₁₈ClN₃O₄S₂
- canonical SMILES
- C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl
- medical condition treated
- arterial hypertension
- World Health Organisation international non-proprietary name
- cyclopenthiazide
- defined daily dose
- 0.5
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Synthesis
- Contraindications
- See also
- References
Cyclopenthiazide (trade name Navidrex) is a thiazide diuretic used in the treatment of heart failure and hypertension.
==Synthesis== thumb|center|700px|Cyclopenthiazide synthesis:
Excerpted from Wikipedia’s “cyclopenthiazide” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0