cyclopentolate-(RS)

Also known as (+-)-cyclopentolate, beta-(dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate, 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate, alpha-(1-hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester, 1-hydroxy-alpha-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl ester, 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid beta-(dimethylamino)ethyl ester, beta-dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate, 2-(dimethylamino)ethyl 1-hydroxy-alpha-phenylcyclopentaneacetate

Cyclopentolate is a muscarinic antagonist. It is commonly used as an eye drop during pediatric eye examinations to dilate the eye (mydriatic) and prevent the eye from focusing/accommodating (cycloplegic). Cyclopentolate or atropine can also be administered to reverse muscarinic and central nervous system effects of indirect cholinomimetic (anti-AChase) administration.

Chemical data

Formula: C17H25NO3
Molecular weight: 291.4 g/mol
IUPAC name: 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate
SMILES: CN(C)CCOC(=O)C(C1=CC=CC=C1)C2(CCCC2)O
InChIKey: SKYSRIRYMSLOIN-UHFFFAOYSA-N
XLogP: 2.7
Polar surface area: 49.8 Å²
H-bond donors: 1
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

2 papers

School bus accommodation-relaxing skiascopy.Clinical ophthalmology (Auckland, N.Z.) · 2019
Brazilian guideline for pediatric cycloplegia and mydriasis.Arquivos brasileiros de oftalmologia · 2023

via PubMed

Wikidata facts

Mass: 291.183444

Show 4 more facts

chemical formula: C₁₇H₂₅NO₃
canonical SMILES: CN(C)CCOC(=O)C(C1=CC=CC=C1)C2(CCCC2)O
World Health Organisation international non-proprietary name: cyclopentolate
Commons category: Cyclopentolate

Sources (4)

via Wikidata · CC0

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