manitol

Also known as Aridol Kit, Resectisol, e421, Fraxinine, (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol, D-Mannitol, Mannite, Manna Sugar

compuesto químico

OverviewAI-generated

D-(-)-mannitol is a chemical compound with the molecular formula C₆H₁₄O₆. Its IUPAC name is (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol. The substance has a mass of 182.079 and a melting point of 166. It is characterized by a defined daily dose of 0.8.

Chemical properties include an xlogp value of -3.1 and a topological polar surface area of 121. The molecule contains six hydrogen bond donors and six hydrogen bond acceptors, with a net charge of 0.

D-(-)-mannitol is referenced by 575 other encyclopedia articles. A search for the term in PubMed yields a count of 26883 entries.

Synthesized by Vinony from 21 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

In the Vinony graph

Vinony's link graph records 575 inbound references to manitol, and connects out to laxative, alcohols and kidney failure.

Vinony files it under Drugs with non-standard legal status, ECHA InfoCard ID from Wikidata and E-number additives.

Vinony links it to 38 Wikipedia language editions.

Key facts

Drug.verifiedrevid: 456482551
Drug.image: D-Mannitol structure.svg
Drug.image_class: skin-invert-image
Drug.image2: Mannitol-3D-balls.png
Drug.image_class2: bg-transparent
Drug.tradename: Osmitrol, Bronchitol, others
Drug.DailyMedID: Mannitol
Drug.pregnancy_AU: B2
Drug.routes_of_administration: Intravenous, by mouth, inhalation
Drug.ATC_prefix: A06
Drug.ATC_suffix: AD16
Drug.legal_CA: Rx-only
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.bioavailability: ~7%
Drug.metabolism: Liver, negligible
Drug.elimination_half life: 100 minutes
Drug.excretion: Kidney: 90%

via Wikipedia infobox

Chemical data

Formula: C6H14O6
Molecular weight: 182.17 g/mol
IUPAC name: (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
SMILES: C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
InChIKey: FBPFZTCFMRRESA-KVTDHHQDSA-N
XLogP: -3.1
Polar surface area: 121 Å²
H-bond donors: 6
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1982
Admin. routes: parenteral, topical
Indications: injury, stroke, Bronchiectasis, hypotension

via ChEMBL · EBI

Research

26,883 papers

Archaeal hyperthermostable mannitol dehydrogenases: A promising industrial enzymes for d-mannitol synthesis.Food research international (Ottawa, Ont.) · 2020
D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism.Cells · 2021
Liquid-liquid transition kinetics in D-mannitol.The Journal of chemical physics · 2022
D-mannitol metabolism by Aspergillus candidus.Journal of bacteriology · 1969
[Characterization of a D-mannitol oxidase from Paenibacillus sp. and its application in the preparation of D-mannose].Sheng wu gong cheng xue bao = Chinese journal of biotechnology · 2023

via PubMed

Wikidata facts

Mass: 182.079
Manufacturer: Pfizer
Has use: sweetener

Show 11 more facts

defined daily dose: 0.8
chemical formula: C₆H₁₄O₆
medical condition treated: cerebral edema
isomeric SMILES: C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
canonical SMILES: C(C(C(C(C(CO)O)O)O)O)O
Commons category: Mannitol
subject has role: essential medicine
melting point: 166
described by source: Encyclopædia Britannica 11th edition
legal status (medicine): boxed warning
stereoisomer of: D-iditol

Sources (7)

via Wikidata · CC0

Article · Español

El manitol es un edulcorante obtenido de la hidrogenación del azúcar manosa. Pertenece al grupo de edulcorantes denominados polioles o polialcoholes. El manitol es estereoisómero del sorbitol. Es común encontrarlo naturalmente en alimentos de origen vegetal, tales como remolacha, apio, aceitunas y algas marinas. El manitol tiene alrededor del 0,4 al 0,5 poder edulcorante en comparación a la sacarosa y sus propiedades son bastante similares a las del sorbitol, a diferencia de su solubilidad, que es poca en comparación. El manitol puede ser producido a partir de la sacarosa o dextrosa y también como subproducto de algunas fermentaciones.

Abstract from DBpedia / Wikipedia · CC BY-SA