Structure via PubChem · Public domain (PubChem)
マンニトール
Sign in to saveAlso known as Aridol Kit, Resectisol, e421, Fraxinine, (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol, D-Mannitol, Mannite, Manna Sugar
Mannitol is a type of sugar alcohol used as a sweetener and medication. It is used as a low-calorie sweetener as it is poorly absorbed by the intestines. As a medication, it is used to decrease pressure in the eyes, as in glaucoma, and to lower increased intracranial pressure. Medically, it is given by injection or inhalation. Effects typically begin within 15 minutes and last up to 8 hours.
OverviewAI-generated
D-(-)-mannitol is a chemical compound with the molecular formula C₆H₁₄O₆. Its IUPAC name is (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol. The substance has a mass of 182.079 and a melting point of 166. It is characterized by a defined daily dose of 0.8.
Chemical properties include an xlogp value of -3.1 and a topological polar surface area of 121. The molecule contains six hydrogen bond donors and six hydrogen bond acceptors, with a net charge of 0.
D-(-)-mannitol is referenced by 575 other encyclopedia articles. A search for the term in PubMed yields a count of 26883 entries.
Synthesized by Vinony from 21 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.verifiedrevid
- 456482551
- Drug.image
- D-Mannitol structure.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Mannitol-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Osmitrol, Bronchitol, others
- Drug.DailyMedID
- Mannitol
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- Intravenous, by mouth, inhalation
- Drug.ATC_prefix
- A06
- Drug.ATC_suffix
- AD16
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- ~7%
- Drug.metabolism
- Liver, negligible
- Drug.elimination_half life
- 100 minutes
- Drug.excretion
- Kidney: 90%
via Wikipedia infobox
Chemical data
- Formula
- C6H14O6
- Molecular weight
- 182.17 g/mol
- IUPAC name
- (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
- SMILES
- C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
- InChIKey
- FBPFZTCFMRRESA-KVTDHHQDSA-N
- XLogP
- -3.1
- Polar surface area
- 121 Ų
- H-bond donors
- 6
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- parenteral, topical
- Indications
- injury, stroke, Bronchiectasis, hypotension
via ChEMBL · EBI
Research
26,883 papers- Archaeal hyperthermostable mannitol dehydrogenases: A promising industrial enzymes for d-mannitol synthesis.Food research international (Ottawa, Ont.) · 2020
- D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism.Cells · 2021
- Liquid-liquid transition kinetics in D-mannitol.The Journal of chemical physics · 2022
- D-mannitol metabolism by Aspergillus candidus.Journal of bacteriology · 1969
- [Characterization of a D-mannitol oxidase from Paenibacillus sp. and its application in the preparation of D-mannose].Sheng wu gong cheng xue bao = Chinese journal of biotechnology · 2023
via PubMed
Wikidata facts
Show 11 more facts
- defined daily dose
- 0.8
- chemical formula
- C₆H₁₄O₆
- medical condition treated
- cerebral edema
- isomeric SMILES
- C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
- canonical SMILES
- C(C(C(C(C(CO)O)O)O)O)O
- Commons category
- Mannitol
- subject has role
- essential medicine
- melting point
- 166
- described by source
- Encyclopædia Britannica 11th edition
- legal status (medicine)
- boxed warning
- stereoisomer of
- D-iditol
Sources (7)
via Wikidata · CC0
Article · 日本語
マンニトール (mannitol) は糖アルコールの一種である。 ヘキソースに分類され、マンノースの還元体に相当する。マンニット (mannite) とも呼ばれる。光学活性物質であり、天然に多く存在するエナンチオマーは D-マンニトールである。ソルビトールの異性体である。 ヨーロッパから中近東にかけて自生するモクセイ科の（Manna Ash、Fraxinus ornus）の甘い樹液から発見・命名された。マンナトネリコの名はマナにちなむ。 浸透圧調製剤・利尿剤であり、弱い腎臓血管拡張剤でもある。 水溶液中ではプロトンを放出する性質を持つため、水溶液は酸性になる。このため、炭酸ナトリウムなど pH 調整剤を併用することが珍しくない。
Abstract from DBpedia / Wikipedia · CC BY-SA