Structure via PubChem · Public domain (PubChem)
Mannitol
Sign in to saveAlso known as Aridol Kit, Resectisol, e421, Fraxinine, (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol, D-Mannitol, Mannite, Manna Sugar
chemische stof
OverviewAI-generated
D-(-)-mannitol is a chemical compound with the molecular formula C₆H₁₄O₆. Its IUPAC name is (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol. The substance has a mass of 182.079 and a melting point of 166. It is characterized by a defined daily dose of 0.8.
Chemical properties include an xlogp value of -3.1 and a topological polar surface area of 121. The molecule contains six hydrogen bond donors and six hydrogen bond acceptors, with a net charge of 0.
D-(-)-mannitol is referenced by 575 other encyclopedia articles. A search for the term in PubMed yields a count of 26883 entries.
Synthesized by Vinony from 21 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.verifiedrevid
- 456482551
- Drug.image
- D-Mannitol structure.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Mannitol-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Osmitrol, Bronchitol, others
- Drug.DailyMedID
- Mannitol
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- Intravenous, by mouth, inhalation
- Drug.ATC_prefix
- A06
- Drug.ATC_suffix
- AD16
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_EU
- Rx-only
- Drug.bioavailability
- ~7%
- Drug.metabolism
- Liver, negligible
- Drug.elimination_half life
- 100 minutes
- Drug.excretion
- Kidney: 90%
via Wikipedia infobox
Chemical data
- Formula
- C6H14O6
- Molecular weight
- 182.17 g/mol
- IUPAC name
- (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
- SMILES
- C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
- InChIKey
- FBPFZTCFMRRESA-KVTDHHQDSA-N
- XLogP
- -3.1
- Polar surface area
- 121 Ų
- H-bond donors
- 6
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- parenteral, topical
- Indications
- injury, stroke, Bronchiectasis, hypotension
via ChEMBL · EBI
Research
26,883 papers- Archaeal hyperthermostable mannitol dehydrogenases: A promising industrial enzymes for d-mannitol synthesis.Food research international (Ottawa, Ont.) · 2020
- D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism.Cells · 2021
- Liquid-liquid transition kinetics in D-mannitol.The Journal of chemical physics · 2022
- D-mannitol metabolism by Aspergillus candidus.Journal of bacteriology · 1969
- [Characterization of a D-mannitol oxidase from Paenibacillus sp. and its application in the preparation of D-mannose].Sheng wu gong cheng xue bao = Chinese journal of biotechnology · 2023
via PubMed
Wikidata facts
Show 11 more facts
- defined daily dose
- 0.8
- chemical formula
- C₆H₁₄O₆
- medical condition treated
- cerebral edema
- isomeric SMILES
- C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
- canonical SMILES
- C(C(C(C(C(CO)O)O)O)O)O
- Commons category
- Mannitol
- subject has role
- essential medicine
- melting point
- 166
- described by source
- Encyclopædia Britannica 11th edition
- legal status (medicine)
- boxed warning
- stereoisomer of
- D-iditol
Sources (7)
via Wikidata · CC0
Article · Nederlands
Mannitol is een polyol (of suiker-alcohol) die wordt gebruikt als natuurlijke zoetstof, en vulstof. Mannitol is een natuurlijke zoetstof met 0,7 keer de zoetkracht van suiker. Het komt voor in allerlei soorten planten (vooral zeewieren) en heeft een zoete smaak, zonder bijsmaak. Mannitol wordt gebruikt in allerlei voedingsmiddelen. Behalve als zoetstof wordt het vaak ook gebruikt omdat het een betere structuur geeft aan bepaalde voedingsmiddelen en het uitdrogen ervan kan voorkomen. Bij overmatig gebruik (gemiddeld meer dan 15 gram per dag) kan mannitol laxerend werken. De stof is opgenomen in de lijst van essentiële geneesmiddelen van de WHO.
Abstract from DBpedia / Wikipedia · CC BY-SA