daridorexant

Also known as ACT-541468, [(2S)-2-(5-chloro-4-methyl-1H-benzimidazol-2-yl)-2-methylpyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone, nemorexant

In the Vinony graph

Vinony's link graph records 307 inbound references to daridorexant, and connects out to substance abuse, orexin and chemical formula.

Vinony files it under Benzimidazoles, Chemical articles with multiple CAS registry numbers and Chemical articles with multiple PubChem CIDs.

Vinony links it to 11 Wikipedia language editions.

Key facts

Drug.image: Daridorexant structure.svg
Drug.image_class: skin-invert-image
Drug.width: 250
Drug.caption: Above: structure of daridorexant Below: 3D representation of a daridorexant molecule
Drug.image2: Daridorexant 3D.png
Drug.image_class2: bg-transparent
Drug.USAN: Daridorexant hydrochloride
Drug.tradename: Quviviq
Drug.DailyMedID: Daridorexant
Drug.routes_of_administration: By mouth
Drug.class: Dual orexin receptor antagonist; Hypnotic; Sedative
Drug.ATC_prefix: N05
Drug.ATC_suffix: CJ03
Drug.legal_CA: Rx-only
Drug.legal_UK: POM
Drug.legal_US: Schedule IV
Drug.legal_EU: Rx-only
Drug.bioavailability: 62%

via Wikipedia infobox

Chemical data

Formula: C23H23ClN6O2
Molecular weight: 450.9 g/mol
IUPAC name: [(2S)-2-(5-chloro-4-methyl-1H-benzimidazol-2-yl)-2-methylpyrrolidin-1-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone
SMILES: CC1=C(C=CC2=C1N=C(N2)[C@@]3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl
InChIKey: NBGABHGMJVIVBW-QHCPKHFHSA-N
XLogP: 4.1
Polar surface area: 88.9 Å²
H-bond donors: 1
H-bond acceptors: 5
Formal charge: 0

via PubChem

Wikidata facts

Subclass of: chemical compound
Mass: 450.15710165600007

Show 4 more facts

canonical SMILES: CC1=C(C=CC2=C1N=C(N2)C3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl
isomeric SMILES: CC1=C(C=CC2=C1N=C(N2)[C@@]3(CCCN3C(=O)C4=C(C=CC(=C4)OC)N5N=CC=N5)C)Cl
chemical formula: C₂₃H₂₃ClN₆O₂
Commons category: Daridorexant

via Wikidata · CC0

~16 min read

Encyclopedic overview

20 sections

Contents

Medical uses
Available forms
Contraindications
Side effects
Overdose
Interactions
Pharmacology
Pharmacodynamics
Mechanism of action
Pharmacokinetics
Absorption
Distribution
Metabolism
Elimination
Chemistry
History
Society and culture
Legal status
References
Further reading

thumb|Daridorexant blister pack sold in Japan thumb|Left: Quviviq, Right: Lemborexant|Dayvigo　 Quviviq tablets are triangular in shape to prevent them from rolling if dropped.

Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. Daridorexant is taken by mouth.

Excerpted from Wikipedia’s “daridorexant” article, available under the CC BY-SA 4.0 licence.