DDX39B

Also known as BAT1, D6S81E, UAP56, DEAD-box helicase 39B, DExD-box helicase 39B

Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the BAT1 gene.

In the Vinony graph

Within Vinony's link graph, DDX39B is referenced by 3 other articles, and connects out to PubMed, Ensembl genome database project and enzyme.

It is catalogued under the topic Genes on human chromosome 6.

Its subject is documented across 4 Wikipedia language editions.

Gene data

DDX39B

Name: DExD-box helicase 39B
Type: protein-coding
Chromosome: HSCHR6_MHC_QBL_CTG1
Position: 2,786,081–2,802,434 (−)
Aliases: BAT1, D6S81E, UAP56
Ensembl: ENSG00000229496
RefSeq RNA: NM_004640.7, NM_080598.6, NR_037852.2
RefSeq protein: NP_004631.1, NP_542165.1

This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011].

Pathways

RNA transport - Homo sapiens (human)mRNA surveillance pathway - Homo sapiens (human)Spliceosome - Homo sapiens (human)Transport of Mature mRNA derived from an Intron-Containing Transcript Signal Transduction Signaling by Rho GTPases mRNA Splicing - Major Pathway mRNA Splicing mRNA 3'-end processing Transport of Mature Transcript to Cytoplasm

via MyGene.info

Gene · Ensembl

DExD-box helicase 39B

Symbol: DDX39B
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:31,530,217-31,542,451
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein BAT1 PDB 1t5i.png

Show 7 more facts

HomoloGene ID: 48376
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7919
chromosome: human chromosome 6
genomic start: 31497996
genomic end: 31510225
cytogenetic location: 6p21.33

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
External links
Further reading

Spliceosome RNA helicase BAT1 is an enzyme that in humans is encoded by the BAT1 gene.

This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described.

Excerpted from Wikipedia’s “DDX39B” article, available under the CC BY-SA 4.0 licence.