DDX6

Also known as HLR2, P54, RCK, DEAD-box helicase 6, IDDILF, Rck/p54

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.

In the Vinony graph

Vinony's link graph records 3 inbound references to DDX6, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Vinony links it to 4 Wikipedia language editions.

Gene data

DDX6

Name: DEAD-box helicase 6
Type: protein-coding
Position: 118,747,763–118,791,226 (−)
Aliases: HLR2, IDDILF, P54, RCK, Rck/p54
Ensembl: ENSG00000110367
RefSeq RNA: NM_001257191.3, NM_001425145.1, NM_001425146.1, NM_001425147.1, NM_001425148.1
RefSeq protein: NP_001244120.1, NP_001412074.1, NP_001412075.1, NP_001412076.1, NP_001412077.1

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012].

Pathways

RNA degradation - Homo sapiens (human)Deadenylation-dependent mRNA decay mRNA decay by 5' to 3' exoribonuclease Metabolism of RNA

via MyGene.info

Gene · Ensembl

DEAD-box helicase 6

Symbol: DDX6
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:118,747,763-118,791,226
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein DDX6 PDB 1vec.png

Show 8 more facts

HomoloGene ID: 3238
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1656
chromosome: human chromosome 11
genomic start: 118747763
genomic end: 118791164
cytogenetic location: 11q23.3
expressed in: trigeminal ganglion

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein. It may contribute to the cell proliferation and carcinogenesis.

Excerpted from Wikipedia’s “DDX6” article, available under the CC BY-SA 4.0 licence.