Defensin beta 4B

Also known as skin-antimicrobial peptide 1, beta defensin 2, DEFB4A, beta-defensin 4A, defensin, beta 2, SAP1, beta defensin-2, Beta-defensin 2

mammalian protein found in Homo sapiens

Protein · UniProt

Defensin beta 4A

Gene: DEFB4A
Organism: Homo sapiens (Human)
Length: 64 aa
Molecular mass: 7,038 Da
Evidence: 1: Evidence at protein level

Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria (PubMed:10837369, PubMed:9202117). Antimicrobial activity against P.aeruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM (PubMed:10837369). Also exhibits antimicrobial activity against the yeast C.albicans (PubMed:10837369, PubMed:30050988, PubMed:9202117). Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell …

3D-structureAntibioticAntimicrobialDefensinDisulfide bondProteomics identificationReference proteomeSecreted

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Swiss-Prot (reviewed) · via UniProt