Structure via PubChem · Public domain (PubChem)
ebastine
Sign in to saveEbastine is a H1 antihistamine with low potential for causing drowsiness.
Key facts
- Drug.verifiedrevid
- 439227374
- Drug.IUPAC_name
- 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
- Drug.image
- Ebastine.svg
- Drug.image_class
- skin-invert-image
- Drug.caption
- Above: molecular structure of ebastine Below: 3D representation of an ebastine molecule
- Drug.image2
- Ebastine 3D.png
- Drug.image_class2
- bg-transparent
- Drug.routes_of_administration
- Oral
- Drug.protein_bound
- Greater than 95%
- Drug.metabolism
- Hepatic (CYP3A4-mediated), to carebastine
- Drug.elimination_half life
- 15 to 19 hours (carebastine)
- Drug.CAS_number
- 90729-43-4
- Drug.ATC_prefix
- R06
- Drug.ATC_suffix
- AX22
- Drug.PubChem
- 3191
- Drug.ChemSpiderID
- 3079
- Drug.UNII
- TQD7Q784P1
- Drug.ChEMBL
- 305660
via Wikipedia infobox
Chemical data
- Formula
- C32H39NO2
- Molecular weight
- 469.7 g/mol
- IUPAC name
- 4-(4-benzhydryloxypiperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
- SMILES
- CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
- InChIKey
- MJJALKDDGIKVBE-UHFFFAOYSA-N
- XLogP
- 7.2
- Polar surface area
- 29.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
398 papers- Ebastine.2006
- Ebastine: an update of its use in allergic disorders.Drugs · 2000
- Ebastine in allergic rhinitis and chronic idiopathic urticaria.Allergy · 2008
- Ebastine in the Treatment of Allergic Rhinitis and Urticaria: 30 Years of Clinical Studies and Real-World Experience.Journal of investigational allergology & clinical immunology · 2020
- Cardiac effects of ebastine and other antihistamines in humans.Drug safety · 1999
via PubMed
Wikidata facts
- Mass
- 469.298
- Has use
- medication
Show 6 more facts
- chemical formula
- C₃₂H₃₉NO₂
- canonical SMILES
- CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
- defined daily dose
- 10
- route of administration
- oral administration
- subject has role
- H1 antagonist
- Commons category
- Ebastine
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Uses
- Safety
- Pharmacokinetic profile
- Brand names
- See also
- References
- External links
Ebastine is a H1 antihistamine with low potential for causing drowsiness.
It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H1 receptor in peripheral tissue with a low incidence of central side effects, i.e. seldom causing sedation or drowsiness.
Excerpted from Wikipedia’s “ebastine” article, available under the CC BY-SA 4.0 licence.