EIF2A

Also known as EIF-2A, MST089, MSTP004, MSTP089, CDA02, eukaryotic translation initiation factor 2A

Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene. The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

In the Vinony graph

Vinony's link graph records 210 inbound references to EIF2A, and connects out to PubMed, translation and human chromosome 3.

It is catalogued under the topic Genes on human chromosome 3.

Vinony links it to 6 Wikipedia language editions.

Gene data

EIF2A

Name: eukaryotic translation initiation factor 2A
Type: protein-coding
Position: 150,546,678–150,586,798 (+)
Aliases: CDA02, EIF-2A, MST089, MSTP004, MSTP089
Ensembl: ENSG00000144895
RefSeq RNA: NM_001319043.2, NM_001319044.2, NM_001319045.2, NM_001319046.2, NM_032025.5
RefSeq protein: NP_001305972.1, NP_001305973.1, NP_001305974.1, NP_001305975.1, NP_114414.2

This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].