Also known as Insomnia familial fatal, Familial fatal insomnia, FFI, Insomnia, Fatal Familial, Fatal insomnia
Prion disease of the human brain
Fatal insomnia is a neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. The majority of cases are familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically (sporadic fatal insomnia [sFI]). The problems with sleeping typically start out gradually and worsen over time. Eventually, the patient will succumb to total insomnia (agrypnia excitata), most often leading to other symptoms such as speech problems, coordination problems, and dementia. It results in death within a few months to a few years, and there is no known disease-modifying treatment.
Signs and symptoms
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Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).