FBXW8

Also known as FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

Gene data

FBXW8

Name: F-box and WD repeat domain containing 8
Type: protein-coding
Aliases: FBW6, FBW8, FBX29, FBXO29, FBXW6

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

F-box and WD repeat domain containing 8

Symbol: FBXW8
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:116,910,839-117,032,498
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 17731
exact match: identifiers.org/ncbigene/26259
genomic end: 117468953
genomic start: 116910950
cytogenetic location: 12q24.22

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F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.