FBXW8

Also known as FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

Gene data

FBXW8

Name: F-box and WD repeat domain containing 8
Type: protein-coding
Position: 116,910,839–117,032,498 (+)
Aliases: FBW6, FBW8, FBX29, FBXO29, FBXW6
Ensembl: ENSG00000174989
RefSeq RNA: NM_012174.2, NM_153348.3, XM_017019175.3, XM_017019176.2, XM_024448937.2
RefSeq protein: NP_036306.1, NP_699179.2, XP_016874664.1, XP_016874665.1, XP_024304705.2

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process Golgi organization Golgi organization cell population proliferation protein ubiquitination protein ubiquitination protein ubiquitination

Molecular function

protein binding ubiquitin-like ligase-substrate adaptor activity ubiquitin-like ligase-substrate adaptor activity

Cellular component

cytoplasm cytoplasm Golgi apparatus Golgi apparatus centriole cytosol cytosol cytosol

Pathways

Ubiquitin mediated proteolysis - Homo sapiens (human)Adaptive Immune System Immune System Metabolism of proteins Post-translational protein modification Neddylation Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation

via MyGene.info

Gene · Ensembl

F-box and WD repeat domain containing 8

Symbol: FBXW8
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:116,910,839-117,032,498
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 17731
exact match: identifiers.org/ncbigene/26259
genomic end: 117468953
genomic start: 116910950
cytogenetic location: 12q24.22

Sources (4)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

References
Further reading

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.