FBXW8
Sign in to saveAlso known as FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to FBXW8, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 12.
Vinony links it to 5 Wikipedia language editions.
Gene data
FBXW8- Name
- F-box and WD repeat domain containing 8
- Type
- protein-coding
- Position
- 116,910,839–117,032,498 (+)
- Aliases
- FBW6, FBW8, FBX29, FBXO29, FBXW6
- Ensembl
- ENSG00000174989
- RefSeq RNA
- NM_012174.2, NM_153348.3, XM_017019175.3, XM_017019176.2, XM_024448937.2
- RefSeq protein
- NP_036306.1, NP_699179.2, XP_016874664.1, XP_016874665.1, XP_024304705.2
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
F-box and WD repeat domain containing 8
- Symbol
- FBXW8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:116,910,839-117,032,498
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 17731
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/26259
- genomic end
- 117468953
- genomic start
- 116910950
- chromosome
- human chromosome 12
- cytogenetic location
- 12q24.22
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Excerpted from Wikipedia’s “FBXW8” article, available under the CC BY-SA 4.0 licence.