FLT3

Name

fms related receptor tyrosine kinase 3

Type

protein-coding

Position

28,003,274–28,100,592 (−)

Aliases

CD135, FLK-2, FLK2, STK1

Ensembl

ENSG00000122025

RefSeq RNA

NM_001445917.1, NM_004119.3, NR_130706.2, XM_011535015.3, XM_011535018.3

RefSeq protein

NP_001432846.1, NP_004110.2, XP_011533317.1, XP_011533320.1, XP_016875975.1

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015].

via MyGene.info

Gene · Ensembl

fms related receptor tyrosine kinase 3

Symbol

FLT3

Biotype

Protein coding

Organism

Homo sapiens

Location

13:28,003,274-28,100,592

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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