Structure via PubChem · Public domain (PubChem)
flunixin
Sign in to saveAlso known as 2-(alpha(3),alpha(3),alpha(3)-trifluoro-2,3-xylidino)nicotinic acid, Sch 14714, 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxylic acid
Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt. In the United States, it is regulated by the U.S. Food and Drug Administration (FDA), and may only be lawfully distributed by order of a licensed veterinarian. There are many trade names for the product.
In the Vinony graph
Within Vinony's link graph, flunixin is referenced by 293 other articles, and connects out to salicylic acid, metamizole sodium and clonixin.
Vinony files it under Alpha-Amino acids, Anilines and Aromatic acids.
Its subject is documented across 8 Wikipedia language editions.
Chemical data
- Formula
- C14H11F3N2O2
- Molecular weight
- 296.24 g/mol
- IUPAC name
- 2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
- SMILES
- CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
- InChIKey
- NOOCSNJCXJYGPE-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 62.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
964 papers- Flunixin meglumine tissue residues after intravenous administration in goats.Frontiers in veterinary science · 2023
- The pharmacokinetics of transdermal flunixin in lactating dairy goats.Journal of dairy science · 2022
- Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals.Journal of the American Veterinary Medical Association · 1989
- Transdermal Flunixin Meglumine as a Pain Relief in Donkeys: A Pharmacokinetics Pilot Study.Metabolites · 2023
- Efficacy of transdermal flunixin in mitigating castration pain in piglets.Frontiers in pain research (Lausanne, Switzerland) · 2022
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 296.077
Show 5 more facts
- chemical formula
- C₁₄H₁₁F₃N₂O₂
- canonical SMILES
- CC1=C(C=CC=C1NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
- World Health Organisation international non-proprietary name
- flunixin
- subject has role
- non-steroidal anti-inflammatory drug
- Commons category
- Flunixin
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
6 sectionsContents
- Dosage and uses in horses
- Side effects and precautions
- Administration
- See also
- References
- External links
Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt. In the United States, it is regulated by the U.S. Food and Drug Administration (FDA), and may only be lawfully distributed by order of a licensed veterinarian. There are many trade names for the product.
==Dosage and uses in horses== Flunixin is administered at a dose of 1.1 mg/kg. The full analgesic and antipyretic effects usually occur 1–2 hours following treatment, but there is often an effective analgesic effect within approximately 15 minutes. Despite its short plasma half life of 1.6–2.5 hours, effects can persist for up to 30 hours, with maximal effects occurring between 2 and 16 hours. This is likely due to accumulation of the drug at inflammatory foci. Flunixin is primarily eliminated by the kidneys.
Excerpted from Wikipedia’s “flunixin” article, available under the CC BY-SA 4.0 licence.