Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.
Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.
This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition to existing oligosaccharides or the four Protein O-fucosyltransferases (POFUTs) that transfer fucose in alpha1-O linkage directly to serines or threonines in specific protein motifs. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).