FUT2
Sign in to saveAlso known as B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 (fucosyltransferase 2) gene.
Gene data
FUT2- Name
- fucosyltransferase 2 (H blood group)
- Type
- protein-coding
- Aliases
- B12QTL1, SE, SEC2, Se2, sej
This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. The encoded protein is important for the final step in the soluble ABO blood group antigen synthesis pathway. It is also involved in cell-cell interaction, cell surface expression, and cell proliferation. Mutations in this gene are a cause of the H-Bombay blood group where red blood cells lack the H antigen. [provided by RefSeq, May 2022].
via MyGene.info
Gene · Ensembl
fucosyltransferase 2 (H blood group)
- Symbol
- FUT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:48,695,953-48,705,951
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 10325
- exact match
- identifiers.org/ncbigene/2524
- genomic end
- 48705951
- genomic start
- 49199228
- cytogenetic location
- 19q13.33
via Wikidata · CC0
~3 min read
Article
6 sectionsContents
- Role in secretor status
- Clinical significance
- Impact on the gut microbiome
- Consequences for microbial metabolism
- References
- Further reading
Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 (fucosyltransferase 2) gene.
FUT2 is a key enzyme that catalyzes the transfer of L-fucose from guanosine diphosphate-beta-L-fucose to the terminal galactose on both O- and N-linked glycans of cell surface glycoproteins and glycolipids. This enzymatic activity is essential for the synthesis of the H antigen, a precursor required for the formation of ABO blood group antigens, and determines "secretor status"—the presence of blood group antigens in bodily fluids such as saliva. Beyond its role in blood group antigen synthesis, FUT2 influences cell-cell interactions, modulates the composition of the gut microbiome, and impacts susceptibility to infections and autoimmune diseases, highlighting its broad significance in human health and disease.