FZD8
Sign in to saveAlso known as FZ-8, hFZ8, frizzled class receptor 8
Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.
In the Vinony graph
Vinony's link graph records 485 inbound references to FZD8, and connects out to PubMed, Ensembl genome database project and cell surface receptor.
It sits within the topics Genes on human chromosome 10 and G protein-coupled receptors.
Vinony links it to 7 Wikipedia language editions.
Gene data
FZD8- Name
- frizzled class receptor 8
- Type
- protein-coding
- Position
- 35,638,247–35,642,296 (−)
- Aliases
- FZ-8, hFZ8
- Ensembl
- ENSG00000177283
- RefSeq RNA
- NM_031866.3
- RefSeq protein
- NP_114072.1
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
frizzled class receptor 8
- Symbol
- FZD8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:35,638,247-35,642,296
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein FZD8 PDB 1ijy.png
Show 8 more facts
- exact match
- identifiers.org/ncbigene/8325
- HomoloGene ID
- 40606
- found in taxon
- Homo sapiens
- genomic end
- 35642296
- genomic start
- 35638247
- chromosome
- human chromosome 10
- cytogenetic location
- 10p11.21
- expressed in
- spinal ganglia
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.
== Function ==
Excerpted from Wikipedia’s “FZD8” article, available under the CC BY-SA 4.0 licence.