FZD8

Name

frizzled class receptor 8

Type

protein-coding

Position

35,638,247–35,642,296 (−)

Aliases

FZ-8, hFZ8

Ensembl

ENSG00000177283

RefSeq RNA

NM_031866.3

RefSeq protein

NP_114072.1

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image

Protein FZD8 PDB 1ijy.png

via Wikidata · CC0