gadoversetamide

Also known as MP-1177, Gadoversetamid, Gadoversetamida, Gadoversetamidum

Gadoversetamide is a gadolinium-based MRI contrast agent, particularly for imaging of the brain, spine and liver. It is marketed under the trade name OptiMARK.

In the Vinony graph

Within Vinony's link graph, gadoversetamide is referenced by 61 other articles, and connects out to MRI contrast agent, microparticle and brain.

It is catalogued under topics including Drugboxes which contain changes to verified fields, Drug has EMA link and Drugs with no legal status.

Its subject is documented across 6 Wikipedia language editions.

Chemical data

Formula: C20H34GdN5O10
Molecular weight: 661.8 g/mol
IUPAC name: 2-[bis[2-[carboxylatomethyl-[2-(2-methoxyethylamino)-2-oxoethyl]amino]ethyl]amino]acetate;gadolinium(3+)
SMILES: COCCNC(=O)CN(CCN(CCN(CC(=O)NCCOC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]
InChIKey: HBEAOBRDTOXWRZ-UHFFFAOYSA-K
Polar surface area: 207 Å²
H-bond donors: 2
H-bond acceptors: 13
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1999
Admin. routes: parenteral
Indications: Magnetic Resonance Imaging

via ChEMBL · EBI

Research

103 papers

Gadoversetamide.2006
Gadoversetamide: Gd-DTPA-BMEA.2004
Gadolinium-Induced Fibrosis.Annual review of medicine · 2016
Genotoxic effects of gadobutrol and gadoversetamide active substances used in magnetic resonance imaging in human peripheral lymphocytes in vitro.Drug and chemical toxicology · 2022
Assessment of genetic damage induced by gadolinium-based radiocontrast agents.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2022

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 662.154671
Has use: medication

Show 3 more facts

chemical formula: C₂₀H₃₄GdN₅O₁₀
canonical SMILES: COCCNC(=O)CN(CCN(CCN(CC(=O)NCCOC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]
subject has role: contrast agent

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

1 sections

Contents

Notes

Gadoversetamide is a gadolinium-based MRI contrast agent, particularly for imaging of the brain, spine and liver. It is marketed under the trade name OptiMARK.

==Notes==

Excerpted from Wikipedia’s “gadoversetamide” article, available under the CC BY-SA 4.0 licence.