Structure via PubChem · Public domain (PubChem)
gallopamil
Sign in to saveGallopamil (INN) is an L-type calcium channel blocker that is an analog of verapamil. It is used in the treatment of abnormal heart rhythms.
Chemical data
- Formula
- C28H40N2O5
- Molecular weight
- 484.6 g/mol
- IUPAC name
- 5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanenitrile
- SMILES
- CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC
- InChIKey
- XQLWNAFCTODIRK-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 73.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, asthma
via ChEMBL · EBI
Research
1,233 papers- Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease.Drugs · 1994
- Effect of gallopamil on excitation-contraction coupling.General pharmacology · 1996
- Gallopamil: cardiovascular scope of action of a highly specific calcium antagonist.Journal of cardiovascular pharmacology · 1992
- Enantioselective gallopamil protein binding.Chirality · 1993
- Gallopamil and diltiazem: a double-blind, randomized, cross-over trial in effort ischaemia.European heart journal · 1992
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 484.294
Show 3 more facts
- chemical formula
- C₂₈H₄₀N₂O₅
- canonical SMILES
- CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C(=C2)OC)OC)OC
- subject has role
- calcium channel blocker
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Gallopamil (INN) is an L-type calcium channel blocker that is an analog of verapamil. It is used in the treatment of abnormal heart rhythms.
==Synthesis== upright=2|class=skin-invert-image
Excerpted from Wikipedia’s “gallopamil” article, available under the CC BY-SA 4.0 licence.